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2 edition of Mechanisms of relaxation in vascular smooth muscle. found in the catalog.

Mechanisms of relaxation in vascular smooth muscle.

Eissa Mohamed Ammar El-Muradi

Mechanisms of relaxation in vascular smooth muscle.

by Eissa Mohamed Ammar El-Muradi

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  • 10 Currently reading

Published in Bradford .
Written in English


Edition Notes

Ph.D. thesis. Typescript.

Seriestheses
ID Numbers
Open LibraryOL13861491M

Smooth muscle research was very much a second rate activity and lay under a Not more than ten years ago it would have been wellnigh impossible to envisage discussion of the topic of this chapter. Crossbridge Mechanisms of Contraction in Vascular Smooth Muscle | SpringerLinkAuthor: N. L. Stephens, S. K. Kong, G. Morgan. Venous relaxation and cGMP accumulation elicited by bradykinin was abolished by methylene blue but was unaltered by indomethacin. Thus bradykinin and VIP relaxed bovine intrapulmonary artery by endothelium-dependent mechanisms involving the actions of cGMP and cAMP whose formation may be stimulated by endothelium-derived relaxing factor and.

This regulatory mechanism appears to be of unique importance in smooth muscle compared with striated muscle. It is equally clear, however, that there is an important role for protein kinase C in the regulation of smooth muscle tone maintenance, particularly in vascular smooth by: Endothelial Mechanisms Regulating Blood Flow. Since the s, the vascular endothelium has been known to have an important role in the regulation of smooth muscle function and in modulating leukocyte and platelet adhesion to the endothelium. As shown in the figure, various blood borne substances that come in contact with vascular endothelial.

A. Mechanism of Action. Smooth muscle relaxation occurs secondary to the reduction of acetylcholine released at the motor end plate or by direct effects through competition with calcium at the motor end plate or in the cell membrane. 2. B. Metabolism. The kidney primarily excretes magnesium. Caution is indicated for patients with potential.   Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms addresses the vascular smooth muscle function by describing plasma lipoprotein structure, synthesis, and transport in relation to the concepts of altered vascular smooth muscle lipid metabolism leading to the genesis of atherosclerotic Edition: 1.


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Mechanisms of relaxation in vascular smooth muscle by Eissa Mohamed Ammar El-Muradi Download PDF EPUB FB2

In keeping with the aims of this text, this chapter will focus on the principle mechanisms through which vascular smooth muscle functions. Smooth muscle has an important role in regulating the function of a variety of hollow organ systems including the: vasculature, airways, gastrointestinal tract, uterus and reproductive tract, bladder and urethra and several other : David P Wilson.

We demonstrate here that relaxation of isolated preparations of rabbit thoracic aorta and other blood vessels by ACh requires the presence of endothelial cells, and that ACh, acting on muscarinic receptors of these cells, stimulates release of a substance(s) that causes relaxation of the vascular smooth muscle.

We propose that this may be one of the principal mechanisms for ACh-induced vasodilation in vitro. T1 - Mechanisms of direct relaxation of vascular smooth muscle by 17β-estradiol. AU - Gonzales, R. AU - Kanagy, N. Mechanisms of relaxation in vascular smooth muscle. book - /12/1.

Y1 - /12/1. N2 - Previous clinical studies have demonstrated that estrogens have a cardioprotective effect. This is supported by the observation that estrogen relaxes vascular smooth muscle (VSM).Author: Rayna J Gonzales, N.

Kanagy. Multiple mechanisms of vascular smooth muscle relaxation by the activation of Proteinase‐Activated Receptor 2 in mouse mesenteric arterioles. John J McGuire non‐NO/non‐PGI 2 endothelium‐dependent hyperpolarization of vascular smooth muscle is a potential mechanism that has been ascribed to other endothelium‐dependent vasodilators Cited by:   Multiple mechanisms of vascular smooth muscle relaxation by the activation of Proteinase‐Activated Receptor 2 in mouse mesenteric arterioles.

John J McGuire. adenylyl cyclase, and of K + channel activation to vascular smooth muscle relaxation. PAR2 agonist, SLIGRL‐NH 2 Cited by: Abstract. Normally, contractions of smooth muscle, which follow activation of the ATPase properties of myosin by phosphorylation in the presence of calmodulin and Ca (Chapter 2), are terminated by withdrawal of the initiating stimulus followed by a fall in the free cytoplasmic Ca concentration, mediated by the physiological systems that usually maintain the cation at a low by: Multiple mechanisms of vascular smooth muscle relaxation by the activation of Proteinase-Activated Receptor 2 in mouse mesenteric arterioles February British Journal of Pharmacology (1) We describe here a number of pathways by which vascular smooth muscle contraction and stiffness are directly regulated and hence will affect blood pressure.

It should be mentioned that many other indirect pathways are also involved, with a major mechanism being the development of inflammation and subsequent reduction-oxidation reaction (REDOX) signaling pathways (Sorescu et al., ; Cited by: SMOOTH MUSCLE RELAXATION.

Smooth muscle relaxation occurs either as a result of removal of the contractile stimulus or by the direct action of a substance that stimulates inhibition of the contractile mechanism (e.g., atrial natriuretic factor is a vasodilator).Cited by: Vascular smooth muscle (VSM) constitutes most of the tunica media in blood vessels and plays an important role in the control of vascular tone.

Ca2+ is a major regulator of VSM contraction and is strictly regulated by an intricate system of Ca2+ mobilization and Ca2+ homeostatic mechanisms.

The interaction of a physiological agonist with its plasma membrane receptor stimulates the hydrolysis Cited by: Vascular Smooth Muscle Contraction and Relaxation The contractile characteristics and the mechanisms that cause contraction of vascular smooth muscle (VSM) are very different from cardiac muscle.

VSM undergoes slow, sustained, tonic contractions, whereas cardiac muscle contractions are rapid and of relatively short duration (a few hundred milliseconds). Journals & Books; Register Biochemical Pharmacology. Vol Is 1 JunePages Commentary. Mechanisms of endothelium-dependent vascular smooth muscle relaxation.

Author links open overlay panel Michael J Mechanisms of endothelium-dependent vascular smooth muscle relaxation. Author links open overlay panel Cited by:   The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen.

We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function.

on vascular smooth muscle cells that depends on soluble guanylyl cyclase activation and conse-quent increase in intracellular cyclic 3’5’-guanosine monophosphate.1 Additional antia-therogenic functions of EDNO relate to inhibition ofplateletactivity,leucocyteadhesion,andvascu-lar smooth muscle cell proliferation.

ReducedCited by: We conclude that, paradoxically, the same increase in extracellular Ca2+ concentration that causes an increase in endothelial intracellular calcium concentration ([Ca2+]i) to produce EDRF also results in membrane stabilization of the vascular smooth muscle cell to decrease [Ca2+]i and cause relaxation.

These two mechanisms are additive in producing calcium relaxation in the intact by:   The major finding of our study is that PAR2 activation in isolated second-order mesenteric arterioles leads to a NO/NOS/COX-independent mechanism of murine vascular smooth muscle relaxation.

Entirely in keeping with previous reports (Al Ani et al., ; Saifeddine et al., ; Emilsson et al., ; Moffatt & Cocks, ) PAR2 Cited by: At the very least, cyclic GMP accumulation represents a useful biochemical index of the interaction of EDRF with vascular smooth muscle and can be readily exploited, M.

PEACH, H. SINGER and A. LOEB unlike contraction and relaxation, in cultured smooth by:   In this video the mechanism of Smooth muscle relaxation have been discussed in detail. The smooth muscle surrounds the endothelium.

Several studies have suggested that estrogen-induced direct vasorelaxation is due to inhibition of the entry of extracellular Ca 2+ into vascular smooth muscle cells.

20 21 The present study was designed to analyze the mechanism of direct vascular smooth muscle–relaxing action of 17β-estradiol in depolarized rings of rat and mouse by:   Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

L J Ignarro, H Lippton, J C Edwards, W H Baricos, A L Hyman, P J Kadowitz and C A GruetterCited by:. in vascular reactivity or the regulation of vascular smooth muscle contraction and/or vascular tone for the control of blood pressure. For these experiments, investigators have genetically modified a mouse to produce abnormalities in the regulation of vascular tone and/or vascular Cited by: Stefano Taddei, Rosa Maria Bruno, in Encyclopedia of Endocrine Diseases (Second Edition), Therapeutic Indications.

CCBs are used to treat hypertension, angina and arrhythmias (Goodman and Gilman׳s, ).Hypertension. By causing vascular smooth muscle relaxation, CCBs decrease systemic vascular resistance, which lowers arterial blood pressure.

These drugs primarily affect .Although not without controversy, the mechanisms inducing contraction of vascular smooth muscle are relatively well defined. There is a stimulus-induced increase in myoplasmic [Ca 2+] with activation of myosin light chain kinase by the Ca 2+ –calmodulin complex, phosphorylation of the kDa regulatory light chain of myosin, with subsequent cross-bridge cycling and force by: